Tyler Jubenville

Work Experience

University of Minnesota - Masonic Cancer Center

August 2020 - Present

Researcher 3 - Bioinformatics

  • Provided actionable insights from high-dimensional data analysis to optimize validation experiments,
    prioritize biological targets, and developed figures for grant applications and peer reviewed publications

  • Led the integration of complex genomics analyses from a multi-site team of bioinformaticists for publication

  • Developed, packaged, and released new analysis methodologies for emerging sequencing technologies, allowing for robust transposon detection in RNAseq and esTAGseq experiments

  • Managed execution of simultaneous program deliverables while mentoring junior lab members and graduate students in application of bioinformatics and statistics.

  • Collaborated with cross-functional, international teams on functional genomics projects from concept phase through publication.

MicroPort Orthopedics Inc.

June 2017 – April 2020

Reliability Engineer – Post-Market Quality

Project Lead – Complaint Data Remediation and Automation

  • Updated legacy complaint data to new coding system using Natural Language Processing techniques

  • Automation of complaint data and risk analysis using SAS and R

  • Development of complaint trending process to detect significant increases in event frequency or severity

Additional Responsibilities

  • Conduct failure investigations for orthopedic implants and instruments

  • Participate in risk management for new and existing orthopedic products

Plexus Corp.

May 2016-May 2017

Design Engineer – Functional Test

  • Developed manufacturing test fixtures for use in the production of medical equipment

  • Authored and supervised execution of verification test methods for Class II medical device

  • Utilized Agile doc. control software to draft and approve engineering change documentation

  • Conducted electronic component end of life analyses and alternate part selection for customer BOMs

Medtronic – Minimally Invasive Therapies Group

Summer 2015

R&D Engineering Intern – Sustaining

  • Developed and implemented a test plan to prove equivalent performance of a medical device

  • Interacted with international suppliers to implement supply chain solutions and prevent product gap out

  • Ensured device compliance with IEC 60601 patient safety standards

Stryker Instruments – Neuro Spine ENT

Summer 2014

Electrical Engineering Intern – R&D

  • Investigated the viability of a dynamometer test system for electric motor characterization

  • Assisted in hardware troubleshooting and development using electrical lab equipment

  • Designed and assembled system on board prototypes for software development using Pro\E

ArcelorMittal – Indiana Harbor East Finishing

Summer 2013

Associate Engineer – Electrical Intern Summer 2013

  • Updated quality critical equipment to ISO9001 standards

  • Worked with supervisors to implement solutions to quality control issues

  • Communicated with vendors to install remote controls in an overhead crane

Publications

Bhunia MM, Stehn CM, Jubenville TA, Novacek EL, Larsson AT, Madala M, Suppiah S, Velez-Reyes GL, Williams KB, Sokolowski M, Williams RL, Finnerty SJ, Temiz NA, Caride A, Bhagwate AV, Nagaraj NK, Lee JH, Ordog T, Zadeh G, Largaespada DA. Multiomic analyses reveal new targets of polycomb repressor complex 2 in Schwann lineage cells and malignant peripheral nerve sheath tumors. Neurooncol Adv. 2024 Nov 9;6(1):vdae188. doi: 10.1093/noajnl/vdae188. PMID: 39620202; PMCID: PMC11606644.

Nikrad JA, Galvin RT, Sheehy MM, Novacek EL, Jacobsen KL, Corbière SMAS, Beckmann PJ, Jubenville TA, Yamamoto M, Largaespada DA. Conditionally replicative adenovirus as a therapy for malignant peripheral nerve sheath tumors. Mol Ther Oncol. 2024 Feb 28;32(2):200783. doi: 10.1016/j.omton.2024.200783. PMID: 38595983; PMCID: PMC10959710.

Williams KB, Larsson AT, Keller BJ, Chaney KE, Williams RL, Bhunia MM, Draper GM, Jubenville TA, Hudson WA, Moertel CL, Ratner N, Largaespada DA. Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors. bioRxiv [Preprint]. 2024 Nov 1:2024.03.25.585959. doi: 10.1101/2024.03.25.585959. PMID: 38585724; PMCID: PMC10996510.

Osum SH, Oribamise EI, Corbière SMAS, Taisto M, Jubenville T, Coutts A, Kirstein MN, Fisher J, Moertel C, Du M, Bedwell D, Largaespada DA, Watson AL. Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1. Mol Ther Nucleic Acids. 2023 Jun 26;33:227-239. doi: 10.1016/j.omtn.2023.06.018. PMID: 37520682; PMCID: PMC10384610.

Larsson AT, Bhatia H, Calizo A, Pollard K, Zhang X, Conniff E, Tibbitts JF, Rono E, Cummins K, Osum SH, Williams KB, Crampton AL, Jubenville T, Schefer D, Yang K, Lyu Y, Pino JC, Bade J, Gross JM, Lisok A, Dehner CA, Chrisinger JSA, He K, Gosline SJC, Pratilas CA, Largaespada DA, Wood DK, Hirbe AC. Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology. Neuro Oncol. 2023 Nov 2;25(11):2044-2057. doi: 10.1093/neuonc/noad097. PMID: 37246765; PMCID: PMC10628938.

Education

University of Minnesota

Expected Fall 2025

M.S. Biostatistics

Michigan Technological University

Fall 2011 - Spring 2016

B.S. Electrical Engineering

B.S. Biomedical Engineering

Honors:

  • Graduated Cum Laude

  • Eta Kappa Nu Electrical Engineering Honor Society

  • Tau Beta Pi Engineering Honor Society

Project Experience

Michigan Technological University Senior Design

Fall 2015-Spring 2016

Sponsor: Medtronic Neuromodulation

Objective: Investigate efficacy of BlueTooth Low Energy as an interface for implantable devices

  • Developed HFSS model to simulate BTLE propagation through human tissue

  • Researched and developed test plan to validate software model with hardware and tissue analogs

  • Coordinated team efforts to meet both internal and external deadlines